Water → HCID 18975622, compound

Participants

Reaction Steps

A mixture of methyl (2,4-dimethyl-6-chloro-5-pyrimidinyl)-acetate (0.5 g, 23 mmol), 1-(2,6-dichlorobenzyl)-1H-pyrazol-3-on (5.80 g, 23 mmol) and potassium carbonate (10.0 g, 70 mmol) in dimethylformamide (30 ml) is heated at +130° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-(2,6-dichlorobenzyl)-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as a yellow oil.

Provenance & Evidence