Water → HCID 18975622, compound

HRID 2393336Notes

Reaction equation

HRID 2393336 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4](Cl)[N:3]=1.[Cl:15][C:16]1[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:17]=1[CH2:18][N:19]1[CH:23]=[CH:22][C:21](=[O:24])[NH:20]1.C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O.CCOCC>[CH3:1][C:2]1[N:7]=[C:6]([CH3:8])[C:5]([CH2:9][C:10]([O:12][CH3:13])=[O:11])=[C:4]([O:24][C:21]2[CH:22]=[CH:23][N:19]([CH2:18][C:17]3[C:16]([Cl:15])=[CH:28][CH:27]=[CH:26][C:25]=3[Cl:29])[N:20]=2)[N:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 18975620HCID 18975620, compoundHCID 54017032HCID 54017032, compound

Product 1

HCID 18975622HCID 18975622, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of methyl (2,4-dimethyl-6-chloro-5-pyrimidinyl)-acetate (0.5 g, 23 mmol), 1-(2,6-dichlorobenzyl)-1H-pyrazol-3-on (5.80 g, 23 mmol) and potassium carbonate (10.0 g, 70 mmol) in dimethylformamide (30 ml) is heated at +130° C. for 2 hours. Addition of water, extraction with ether and drying gives the intermediate methyl 2-[2,4-dimethyl-6-(1-(2,6-dichlorobenzyl)-1H-pyrazol-3-yloxy)-pyrimidin-5-yl]-acetate as a yellow oil.

Workup

  1. temperatureis heated at +130° C. for 2 hours
  2. customdrying

Sources & evidence

ORD record
ord-b75748bba3e840a883c72c98da8ebaae
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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