Acrylamide → HCID 18975619, compound

HRID 2393340Notes

Reaction equation

HRID 2393340 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[NH:10][NH2:11].[C:12](N)(=[O:15])[CH:13]=[CH2:14].[Na]>C(O)C.C1(C)C=CC=CC=1>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([Cl:9])=[CH:5][C:4]=1[N:10]1[CH2:14][CH2:13][C:12](=[O:15])[NH:11]1

Participants

6

Reactant 3

HCID 6579AcrylamideHCID 3084937(2,5-Dichlorophenyl)hydrazine monohydrochlorideHCID 5360545Sodium

Product 1

HCID 18975619HCID 18975619, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 1140TolueneSolvent

Procedure

2,5-Dichlorophenylhydrazine hydrochloride (240 g, 1.1 mol) and acrylamide (100 g, 1.4 mol) is refluxed in a solution of sodium (56 g, 2.4 mol) in ethanol (1000 ml) and toluene (1000 ml) for 3 hours. Evaporation of the solvents, acidification with acetic acid dilution with water, filtration and drying (high vacuum, +100° C.) gives the 1-(2,5-dichlorophenyl)-3-pyrazolidone.

Workup

  1. customEvaporation of the solvents, acidification with acetic acid dilution
  2. filtrationwith water, filtration
  3. customdrying (high vacuum, +100° C.)

Sources & evidence

ORD record
ord-f720fd69f2e04dce9921140d2ca36ee8
Source dataset
uspto-grants-1998_09
Patent number
US05807863

Reaction notes

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