Dimethylformamide → HCID 67015157, compound

HRID 2393366Notes

Reaction equation

HRID 2393366 reaction equation
[C:1]([NH:4][C:5]1[CH:28]=[CH:27][C:8]([CH:9]=[C:10]2[C:22]3[N:21]4[CH:23]=[CH:24][N:25]=[C:20]4[C:19](=[O:26])[NH:18][C:17]=3[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]2=3)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].CN(C)C=O>[Pd].CO>[C:1]([NH:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:9][CH:10]2[C:22]3[N:21]4[CH:23]=[CH:24][N:25]=[C:20]4[C:19](=[O:26])[NH:18][C:17]=3[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]2=3)=[CH:27][CH:28]=1)(=[O:3])[CH3:2]

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 70203234HCID 70203234, compound

Product 1

HCID 67015157HCID 67015157, compoundYield 25.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The process is performed as in Example 3 but starting with 4.7 g of 10-(4-acetylaminobenzylidene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 250 ml of dimethylformamide, 50 ml of methanol and 0.6 g of 10% palladium-on-charcoal for 26 hours. 1.2 g of 10-(4-acetylaminobenzyl)-5H,10H-imidazo[1,2-a]indeno-[1,2-e]pyrazin-4-one are obtained in the form of a cream-white solid melting above 260° C. (Analysis, % calculated C: 71.34, H: 4.90, N: 15.13, O: 8.64, % found C: 71.3, H: 4.7, N: 15.3, O: 8.3).

Sources & evidence

ORD record
ord-2cc33d34418544cbab00625e87ff0b8c
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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