Hydrochloric Acid → HCID 86753084, compound

Participants

Reaction Conditions

Reaction Steps

8-Amino-10-(carboxymethylene)-5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one dihydrochloride may be obtained according to the following procedure: 35.5 g of 8-nitro-10-(carboxymethylene)-5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one are added to 74.5 g of stannous chloride dihydrate in 550 ml of concentrated hydrochloric acid, followed by heating at 40° C. for 4 hours. After cooling to 25° C., the mixture is filtered and then washed with 3 times 200 ml of distilled water and twice 100 ml of acetone. The solid is dried at 60° C. under reduced pressure (1 mmHg; 0.13 kPa). 37.45 g of 8-amino-10-(carboxymethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one dihydrochloride are obtained in the form of a yellow solid, the melting point of which is greater than 260° C.

Provenance & Evidence