Hydrochloric Acid → HCID 86753084, compound

HRID 2393390Notes

Reaction equation

HRID 2393390 reaction equation
[N+:1]([C:4]1[CH:20]=[CH:19][C:18]2[C:9]3[NH:10][C:11](=[O:17])[C:12]4[N:13]([CH:14]=[CH:15][N:16]=4)[C:8]=3[C:7](=[CH:21][C:22]([OH:24])=[O:23])[C:6]=2[CH:5]=1)([O-])=O.[ClH:25]>>[ClH:25].[ClH:25].[NH2:1][C:4]1[CH:20]=[CH:19][C:18]2[C:9]3[NH:10][C:11](=[O:17])[C:12]4[N:13]([CH:14]=[CH:15][N:16]=4)[C:8]=3[C:7](=[CH:21][C:22]([OH:24])=[O:23])[C:6]=2[CH:5]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70203222HCID 70203222, compound

Product 1

HCID 86753084HCID 86753084, compound

Conditions

Temperature
40 °C

Procedure

8-Amino-10-(carboxymethylene)-5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one dihydrochloride may be obtained according to the following procedure: 35.5 g of 8-nitro-10-(carboxymethylene)-5H,10H-imidazo-[1,2-a]indeno[1,2-e]pyrazin-4-one are added to 74.5 g of stannous chloride dihydrate in 550 ml of concentrated hydrochloric acid, followed by heating at 40° C. for 4 hours. After cooling to 25° C., the mixture is filtered and then washed with 3 times 200 ml of distilled water and twice 100 ml of acetone. The solid is dried at 60° C. under reduced pressure (1 mmHg; 0.13 kPa). 37.45 g of 8-amino-10-(carboxymethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one dihydrochloride are obtained in the form of a yellow solid, the melting point of which is greater than 260° C.

Workup

  1. temperatureAfter cooling to 25° C.
  2. filtrationthe mixture is filtered
  3. washwashed with 3 times 200 ml of distilled water and twice 100 ml of acetone
  4. customThe solid is dried at 60° C. under reduced pressure (1 mmHg; 0.13 kPa)

Sources & evidence

ORD record
ord-6ac983e66dc04a3f997eb1ba61581b3f
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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