反应详情

A suspension of 550 mg of (10 RS)-10-acetamido-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-4-one in 30 ml of 4N hydrochloric acid is refluxed for 2 hours. The reaction medium is cooled and filtered on a sinter funnel. The solid obtained is recrystallized from 40 ml of ethanol. 130 mg of (10 RS)-10-amino-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride are obtained in the form of a grey solid melting above 260° C. (Analysis, % calculated C: 67.3, H: 5.4, Cl: 9.0, N: 14.3, O: 4.1; % found C: 67.1, H: 5.3, Cl: 9.0, N: 14.1, O: 4.1).

1. temperatureis refluxed for 2 hours
2. temperatureThe reaction medium is cooled
3. filtrationfiltered on a sinter funnel
4. customThe solid obtained
5. customis recrystallized from 40 ml of ethanol