Hydrochloric Acid → (10 RS)-10-amino-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride

HRID 2393398Notes

Reaction equation

HRID 2393398 reaction equation
C([NH:4][C:5]1([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2)(=O)C.[ClH:31]>>[ClH:31].[NH2:4][C:5]1([CH2:22][CH2:23][CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 70202950(10 RS)-10-acetamido-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e)pyrazin-4-one

Product 1

HCID 86753087(10 RS)-10-amino-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride

Procedure

A suspension of 550 mg of (10 RS)-10-acetamido-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-4-one in 30 ml of 4N hydrochloric acid is refluxed for 2 hours. The reaction medium is cooled and filtered on a sinter funnel. The solid obtained is recrystallized from 40 ml of ethanol. 130 mg of (10 RS)-10-amino-10-(3-phenylpropyl)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one hydrochloride are obtained in the form of a grey solid melting above 260° C. (Analysis, % calculated C: 67.3, H: 5.4, Cl: 9.0, N: 14.3, O: 4.1; % found C: 67.1, H: 5.3, Cl: 9.0, N: 14.1, O: 4.1).

Workup

  1. temperatureis refluxed for 2 hours
  2. temperatureThe reaction medium is cooled
  3. filtrationfiltered on a sinter funnel
  4. customThe solid obtained
  5. customis recrystallized from 40 ml of ethanol

Sources & evidence

ORD record
ord-d54ffe4d5af94f9f806647ae93d3a72f
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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