反应详情

A solution of 0.52 g of ethyl 5-(10-methyl-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]-pyrazin-10-yl)valerate in 3 ml of 1N sodium hydroxide is stirred overnight at a temperature in the region of 20° C. The mixture is then treated with 3 ml of 1N hydrochloric acid and the precipitate formed is filtered off. The solid obtained is washed with distilled water (2×10 ml) and with ethyl ether (3×10 ml), and dried at 60° C. under vacuum (1 mmHg; 0.13 kPa). 0.4 g of 5-(10-methyl-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-10-yl)valeric acid is obtained in the form of an ochre solid melting above 260° C. (Analysis, % calculated C: 67.64, H: 5.68, N: 12.45, O: 14.23, % found C: 67.6, H: 5.8, N: 12.5).

1. customthe precipitate formed
2. filtrationis filtered off
3. customThe solid obtained
4. washis washed with distilled water (2×10 ml) and with ethyl ether (3×10 ml)
5. customdried at 60° C. under vacuum (1 mmHg; 0.13 kPa)