Hydrochloric Acid → HCID 10066640, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 0.75 g of methyl [8-(3-methylureido)-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-10-yl]acetate and 4 ml of 1N sodium hydroxide is heated at a temperature in the region of 35° C. for 2 hours. The mixture is acidified with 1N hydrochloric acid and the precipitate formed is filtered off, washed with distilled water and dried at 60° C. under vacuum (1 mmHg; 0.13 kPa). 0.33 g of [8-(3-methylureido)-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-10-yl]acetic acid is obtained in the form of a yellow solid melting above 260° C. (Analysis, % calculated C: 57.79, H: 4.28, N: 19.82, O: 18.11, % found C: 57.8, H: 4.3, N: 19.8).

Provenance & Evidence