Hydrochloric Acid → HCID 10066640, compound

HRID 2393411Notes

Reaction equation

HRID 2393411 reaction equation
[CH3:1][NH:2][C:3](=[O:27])[NH:4][C:5]1[CH:21]=[CH:20][C:19]2[C:10]3[NH:11][C:12](=[O:18])[C:13]4[N:14]([CH:15]=[CH:16][N:17]=4)[C:9]=3[CH:8]([CH2:22][C:23]([O:25]C)=[O:24])[C:7]=2[CH:6]=1.[OH-].[Na+].Cl>>[CH3:1][NH:2][C:3](=[O:27])[NH:4][C:5]1[CH:21]=[CH:20][C:19]2[C:10]3[NH:11][C:12](=[O:18])[C:13]4[N:14]([CH:15]=[CH:16][N:17]=4)[C:9]=3[CH:8]([CH2:22][C:23]([OH:25])=[O:24])[C:7]=2[CH:6]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86753090HCID 86753090, compound

Product 1

HCID 10066640HCID 10066640, compoundYield 45.7%

Conditions

Temperature
35 °C

Procedure

A mixture of 0.75 g of methyl [8-(3-methylureido)-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-10-yl]acetate and 4 ml of 1N sodium hydroxide is heated at a temperature in the region of 35° C. for 2 hours. The mixture is acidified with 1N hydrochloric acid and the precipitate formed is filtered off, washed with distilled water and dried at 60° C. under vacuum (1 mmHg; 0.13 kPa). 0.33 g of [8-(3-methylureido)-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]-indeno[1,2-e]pyrazin-10-yl]acetic acid is obtained in the form of a yellow solid melting above 260° C. (Analysis, % calculated C: 57.79, H: 4.28, N: 19.82, O: 18.11, % found C: 57.8, H: 4.3, N: 19.8).

Workup

  1. customthe precipitate formed
  2. filtrationis filtered off
  3. washwashed with distilled water
  4. customdried at 60° C. under vacuum (1 mmHg; 0.13 kPa)

Sources & evidence

ORD record
ord-8acbaba83b8047cd8b5a356384d29e40
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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