Hydrochloric Acid → HCID 131720823, compound

HRID 2393418Notes

Reaction equation

HRID 2393418 reaction equation
C([NH:4][C:5]1([CH2:22][CH3:23])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2)(=O)C.[ClH:24]>C(O)C>[ClH:24].[NH2:4][C:5]1([CH2:22][CH3:23])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2.[ClH:24].[ClH:24].[NH2:4][C:5]1([CH2:22][CH3:23])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18975405HCID 18975405, compound

Product 1

HCID 131720823HCID 131720823, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.46 g of 10-acetamido-10-ethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one is dissolved in 25 ml of boiling 2N hydrochloric acid and the solution is stirred for 1 hours at boiling, cooled and concentrated to dryness under reduced pressure (15 mmHg; 2 kPa) at 60° C. The product obtained is suspended in 15 ml of ethanol and the insoluble product is isolated by filtration, washed twice with 10 ml in total of ethanol and dried under reduced pressure (1 mmHg; 0.13 kPa) at 100° C. 0.28 g of 10-amino-10-ethyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one sesquihydrochloride is thus obtained, decomposing without melting above 250° C. (Analysis, % calculated C: 56.13, H: 4.87, Cl: 16.57, N: 17.45, O: 4.98, % found C: 56.2, H: 4.5, Cl: 16.5, N: 17.2).

Workup

  1. temperaturecooled
  2. concentrationconcentrated to dryness under reduced pressure (15 mmHg; 2 kPa) at 60° C
  3. customThe product obtained
  4. customthe insoluble product is isolated by filtration
  5. washwashed twice with 10 ml in total of ethanol
  6. customdried under reduced pressure (1 mmHg; 0.13 kPa) at 100° C

Sources & evidence

ORD record
ord-43298e91d4704012809bbffe78d3bdef
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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