Hydrochloric Acid → HCID 131720824, compound

HRID 2393419Notes

Reaction equation

HRID 2393419 reaction equation
C([NH:4][C:5]1([CH2:22][CH2:23][CH3:24])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2)(=O)C.[ClH:25]>C(O)C>[ClH:25].[NH2:4][C:5]1([CH2:22][CH2:23][CH3:24])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2.[ClH:25].[ClH:25].[NH2:4][C:5]1([CH2:22][CH2:23][CH3:24])[C:17]2[N:16]3[CH:18]=[CH:19][N:20]=[C:15]3[C:14](=[O:21])[NH:13][C:12]=2[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]1=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18975481HCID 18975481, compound

Product 1

HCID 131720824HCID 131720824, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.5 g of 10-acetamido-10-propyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one are dissolved in 80 ml of boiling 2N hydrochloric acid and the solution is stirred for 2 hours at boiling, cooled and concentrated to dryness under reduced pressure (15 mmHg; 2 kPa) at 60° C. The product obtained is suspended in 35 ml of ethanol and the insoluble product is isolated by filtration, washed twice with 20 ml in total of ethanol and dried under reduced pressure (1 mmHg; 0.13 kPa) at 100° C. 0.87 g of 10-amino-10-propyl-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one sesquihydrochloride is thus obtained, decomposing without melting above 250° C. (Analysis, % calculated C: 57.36, H: 5.27, Cl: 15.87, N: 16.72, O: 4.78, % found C: 56.9, H: 5.3, Cl: 16.4, N: 16.4).

Workup

  1. temperaturecooled
  2. concentrationconcentrated to dryness under reduced pressure (15 mmHg; 2 kPa) at 60° C
  3. customThe product obtained
  4. customthe insoluble product is isolated by filtration
  5. washwashed twice with 20 ml in total of ethanol
  6. customdried under reduced pressure (1 mmHg; 0.13 kPa) at 100° C

Sources & evidence

ORD record
ord-649c5da4f771444fad2e8cf05df56610
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

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