Acetic Anhydride → HCID 70206776, compound

HRID 2393424Notes

Reaction equation

HRID 2393424 reaction equation
[S:1]1[C:5]([CH:6]=O)=[CH:4][N:3]=[CH:2]1.[CH:8]1[N:12]2[C:13]3[CH2:24][C:23]4[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=4[C:14]=3[NH:15][C:16](=[O:17])[C:11]2=[N:10][CH:9]=1.C([O-])(=O)C.[NH4+].C(OC(=O)C)(=O)C>>[S:1]1[C:5]([CH:6]=[C:24]2[C:13]3[N:12]4[CH:8]=[CH:9][N:10]=[C:11]4[C:16](=[O:17])[NH:15][C:14]=3[C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:23]2=3)=[CH:4][N:3]=[CH:2]1

Participants

5

Reactant 4

HCID 7918Acetic AnhydrideHCID 517165Ammonium AcetateHCID 27735771,3-Thiazole-5-carbaldehydeHCID 103535495H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one

Product 1

HCID 70206776HCID 70206776, compoundYield 54.5%

Procedure

The process is performed as in Example 92 but starting with 0.45 g of 5-thiazolecarboxaldehyde, 0.45 g of 5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one, 0.2 g of ammonium acetate and 4 ml of acetic anhydride. 0.35 g of 10-(5-thiazolylmethylene)-5H,10H-imidazo[1,2-a]indeno[1,2-e]pyrazin-4-one is obtained in the form of a dark red solid melting above 260° C. (Analysis, % calculated C: 64.14, H: 3.17, N: 17.60, O: 5.03, S: 10.07, % found C: 64.2, N: 17.2, S: 9.7).

Sources & evidence

ORD record
ord-cb473898ac834d9784f4082b76e3240e
Source dataset
uspto-grants-1998_09
Patent number
US05807859

Reaction notes

Loading…