Methyl Isocyanate → HCID 18975160, compound

HRID 2393492Notes

Reaction equation

HRID 2393492 reaction equation
[Cl:1][C:2]1[C:3]([Cl:23])=[CH:4][C:5]2[C:11]([C:12]3[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=3)=[N:10][NH:9][CH:8]([CH3:21])[CH2:7][C:6]=2[CH:22]=1.[CH3:24][N:25]=[C:26]=[O:27]>>[Cl:1][C:2]1[C:3]([Cl:23])=[CH:4][C:5]2[C:11]([C:12]3[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=3)=[N:10][N:9]([C:26](=[O:27])[NH:25][CH3:24])[CH:8]([CH3:21])[CH2:7][C:6]=2[CH:22]=1

Participants

3

Reactant 2

HCID 12228Methyl IsocyanateHCID 18975152HCID 18975152, compound

Product 1

HCID 18975160HCID 18975160, compoundYield 97%

Procedure

0.33 g (0.94 mmoles) of 7,8-dichloro-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine obtained in Example 9, Step C are reacted with methyl isocyanate according to Example 3. The crude product is purified by suspending it in hot ethanol. Thus, 0.37 g (97%) of the title compound are obtained. M.p.: 221°-223° C.

Workup

  1. customThe crude product is purified

Sources & evidence

ORD record
ord-c2fc46eb51ff411f845c394878658807
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

Loading…