Propionic anhydride → HCID 18975145, compound

HRID 2393493Notes

Reaction equation

HRID 2393493 reaction equation
[Br:1][C:2]1[CH:28]=[CH:27][C:5]2[CH2:6][CH:7]([CH3:26])[N:8]([C:20](=[O:25])[C:21](F)(F)F)[N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[C:29](OC(=O)CC)(=O)CC>>[Br:1][C:2]1[CH:28]=[CH:27][C:5]2[CH2:6][CH:7]([CH3:26])[N:8]([C:20](=[O:25])[CH2:21][CH3:29])[N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 31263Propionic anhydrideHCID 18975174HCID 18975174, compound

Product 1

HCID 18975145HCID 18975145, compoundYield 70%

Procedure

1.33 g (3.7 mmoles) of 8-bromo-4-methyl-1-(4-nitrophenyl)-3-trifluoroacetyl-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 22, Step D) are acylated with propionic anhydride using the method of Example 1. The crude product is purified by chromatography over a silicagel column that is eluted with a mixture of hexane and ethyl acetate in a ratio of 9:1. Thus, 1.07 g (70%) of the title compound are obtained. M.p.: 178°-180° C.

Workup

  1. customThe crude product is purified by chromatography over a silicagel column that
  2. washis eluted with a mixture of hexane and ethyl acetate in a ratio of 9:1

Sources & evidence

ORD record
ord-f73d203829c14984a4ca5bd2259f7bbd
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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