Sodium Hydroxide → HCID 18975181, compound

HRID 2393496Notes

Reaction equation

HRID 2393496 reaction equation
[Br:1][C:2]1[CH:27]=[CH:26][C:5]2[CH2:6][CH:7]([CH3:25])[N:8](C(OCC)=O)[N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[OH-].[Na+]>CO.O>[Br:1][C:2]1[CH:27]=[CH:26][C:5]2[CH2:6][CH:7]([CH3:25])[NH:8][N:9]=[C:10]([C:11]3[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=3)[C:4]=2[CH:3]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 18975139HCID 18975139, compound

Product 1

HCID 18975181HCID 18975181, compoundYield 92.3%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

5.20 g (12 mmoles) of 8-bromo-3-ethoxycarbonyl-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 32) are boiled in 104 ml of methanol with 6 ml of 10N sodium hydroxide solution for 2 hours. After cooling, the reaction mixture is diluted with 104 ml of water, and the precipitated crystals are filtered. Thus, 3.99 g (92%) of the title compound are obtained. M.p.: 125°-130° C.

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated crystals are filtered

Sources & evidence

ORD record
ord-7775230690804426aefffe80be8da9ff
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

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