Sodium Hydroxide → HCID 18975181, compound

Participants

Reaction Steps

5.20 g (12 mmoles) of 8-bromo-3-ethoxycarbonyl-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 32) are boiled in 104 ml of methanol with 6 ml of 10N sodium hydroxide solution for 2 hours. After cooling, the reaction mixture is diluted with 104 ml of water, and the precipitated crystals are filtered. Thus, 3.99 g (92%) of the title compound are obtained. M.p.: 125°-130° C.

Provenance & Evidence