Isopropyl isocyanate → HCID 18975173, compound

HRID 2393499Notes

Reaction equation

HRID 2393499 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][CH:7]([CH3:20])[NH:8][N:9]=[C:10]([C:11]3[CH:16]=[CH:15][C:14]([N+:17]([O-:19])=[O:18])=[CH:13][CH:12]=3)[C:4]=2[CH:3]=1.[CH:23]([N:26]=[C:27]=[O:28])([CH3:25])[CH3:24]>>[CH:23]([NH:26][C:27]([N:8]1[CH:7]([CH3:20])[CH2:6][C:5]2[CH:21]=[CH:22][C:2]([Cl:1])=[CH:3][C:4]=2[C:10]([C:11]2[CH:12]=[CH:13][C:14]([N+:17]([O-:19])=[O:18])=[CH:15][CH:16]=2)=[N:9]1)=[O:28])([CH3:25])[CH3:24]

Participants

3

Reactant 2

HCID 61277Isopropyl isocyanateHCID 18975135HCID 18975135, compound

Product 1

HCID 18975173HCID 18975173, compoundYield 53%

Procedure

0.6 g (1.9 mmoles) of 8-chloro-4-methyl-1-(4-nitrophenyl)-4,5-dihydro-3H-2,3-benzodiazepine (prepared in Example 5, Step D or in Example 36, starting compound) are reacted with isopropyl isocyanate according to the method of Example 44. The crude product is recrystallized from ethanol. Thus, 0.4 g (53%) of the title compound are obtained. M.p.: 172°-174° C.

Workup

  1. customThe crude product is recrystallized from ethanol

Sources & evidence

ORD record
ord-38087e68b6ee46af90689f414faf5e7c
Source dataset
uspto-grants-1998_09
Patent number
US05807851

Reaction notes

Loading…