Methyl propiolate → HCID 18976127, compound

HRID 2393517Notes

Reaction equation

HRID 2393517 reaction equation
[C:1]1([C:7]2[O:12][C:11]3[CH:13]=[CH:14][CH:15]=[CH:16][C:10]=3[O:9][CH:8]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[C:17]([O:21][CH3:22])(=[O:20])[C:18]#[CH:19]>>[CH2:6]1[C:1]2=[C:7]3[CH:8]([CH:19]=[C:18]([C:17]([O:21][CH3:22])=[O:20])[CH:2]2[CH2:3][CH2:4][CH2:5]1)[O:9][C:10]1[C:11](=[CH:13][CH:14]=[CH:15][CH:16]=1)[O:12]3

Participants

3

Reactant 2

HCID 13536Methyl propiolateHCID 18976112HCID 18976112, compound

Product 1

HCID 18976127HCID 18976127, compound

Procedure

In a sealed tube, 500 mg of 2-(1-cyclohexenyl)-1,4-benzodioxin and 1.4 ml of methyl propiolate are stirred for 22 hours 30 minutes at 70° C. The regioisomers are separated by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 98:2).

Workup

  1. customThe regioisomers are separated by chromatography on silica gel (eluent: petroleum ether/ethyl acetate, 98:2)

Sources & evidence

ORD record
ord-a1405b7313c142409d8c6ab922ed6cca
Source dataset
uspto-grants-1998_09
Patent number
US05807882

Reaction notes

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