HuagongsheHuagongshe Chemistry Print Report · For research reference only
Paclitaxel → Taxane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Paclitaxel | HCID 36314 | — |
| Reactant | Cephalomannine | HCID 6436208 | — |
| Product | Taxane | HCID 9548828 | 20% |
Reaction Steps
Batches of crude plant extracts from Taxus yunnanensis having approximately 15-40% cephalomannine, 50-70% paclitaxel, and approximately 20-35% other taxane/non-taxane components were obtained from the Peoples Republic of China. Bromine reagent was obtained from Fisher Scientific. Silica gel used was ICN Silitech, 32-63 um, 60 Å, ICN Biomedicals, Inc., Aurora, Ohio. All solvents used were either HPLC or ACS grade and were obtained from Spectrum Chemical Mfg. Corp. Purified water used was deionized in-house.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05807888 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-ae2b078ea13f488aa43121dd31ad7418 |
| Source note | uspto-grants-1998_09 |