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HRID2393536

反应详情

EQUATION

反应方程式

HRID 2393536 的结构方程式

REACTANTS

反应物

2
反应SMILES：CC(=O)O[C@H]1C(=O)[C@@]2(C)[C@H]([C@H](OC(=O)c3ccccc3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c4ccccc4)c4ccccc4)C(C)=C1C3(C)C)[C@]1(OC(C)=O)CO[C@@H]1C[C@@H]2O
HCID36314

Paclitaxel

C47H51NO14

反应SMILES：C/C=C(\C)C(=O)N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]1C[C@@]2(O)[C@@H](OC(=O)c3ccccc3)[C@@H]3[C@]4(OC(C)=O)CO[C@@H]4C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C(=C1C)C2(C)C
HCID6436208

未命名化合物

PRODUCTS

产物

1
反应SMILES：C[C@@H]1CCC[C@@]2(C)CC[C@H]3[C@H](C)CC[C@@H](C[C@H]12)C3(C)C
HCID9548828

Taxane

C20H36

收率 20%

PROCEDURE

实验过程

Batches of crude plant extracts from Taxus yunnanensis having approximately 15-40% cephalomannine, 50-70% paclitaxel, and approximately 20-35% other taxane/non-taxane components were obtained from the Peoples Republic of China. Bromine reagent was obtained from Fisher Scientific. Silica gel used was ICN Silitech, 32-63 um, 60 Å, ICN Biomedicals, Inc., Aurora, Ohio. All solvents used were either HPLC or ACS grade and were obtained from Spectrum Chemical Mfg. Corp. Purified water used was deionized in-house.