Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phenylboronic Acid → N-Diaminomethylene-2-ethyl-3-methylsulphonyl-4-phenylbenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Carbamimidoylazanium Chloride | HCID 5460839 | — |
| 반응물 | 6-chloro-N-methylpyridinium chloride | HCID 11744962 | — |
| 반응물 | HCID 18976325 | HCID 18976325 | — |
| 반응물 | Methyl 2-ethyl-3-methylsulphonyl-4-bromobenzoate | HCID 18976391 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | N-Diaminomethylene-2-ethyl-3-methylsulphonyl-4-phenylbenzamide | HCID 18976366 | — |
반응 단계
1.0 g of 2-ethyl-3-methylsulphonyl-4-phenylbenzoic acid [obtainable by reacting methyl 2-ethyl-3-methylsulphonyl-4-bromobenzoate with phenylboronic acid in the presence of tetrakis(triphenylphosphine)-Pd(0) and then hydrolyzing] is dissolved in 15 ml of 1-methylpyrrolidone, and 0.67 g of 1-methyl-2-chloropyridinium chloride is added to this solution which is then stirred for 15 min. 0.9 g of guanidinium chloride and 2.6 ml of diisopropylethylamine are then added, and the mixture is stirred at room temperature for one hour. N-Diaminomethylene-2-ethyl-3-methylsulphonyl-4-phenylbenzamide is obtained after customary working-up.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05807896 |
| 출처 데이터셋 | uspto-grants-1998_09 |
| ORD ID | ord-6010465c3fbf40b29be51b1f250ddb52 |
| 출처 메모 | uspto-grants-1998_09 |