反应详情

1.0 g of 2-ethyl-3-methylsulphonyl-4-phenylbenzoic acid [obtainable by reacting methyl 2-ethyl-3-methylsulphonyl-4-bromobenzoate with phenylboronic acid in the presence of tetrakis(triphenylphosphine)-Pd(0) and then hydrolyzing] is dissolved in 15 ml of 1-methylpyrrolidone, and 0.67 g of 1-methyl-2-chloropyridinium chloride is added to this solution which is then stirred for 15 min. 0.9 g of guanidinium chloride and 2.6 ml of diisopropylethylamine are then added, and the mixture is stirred at room temperature for one hour. N-Diaminomethylene-2-ethyl-3-methylsulphonyl-4-phenylbenzamide is obtained after customary working-up.

1. stirringthe mixture is stirred at room temperature for one hour