Trifluoroacetic acid → HCID 136381089, compound

HRID 2393644Notes

Reaction equation

[NH2:1][C:2](=[N:27][N+:28]([O-:30])=[O:29])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([OH:26])=[CH:22][CH:21]=1)=[O:17])[NH:8]C(OC(C)(C)C)=O.[F:31][C:32]([F:37])([F:36])[C:33]([OH:35])=[O:34]>>[NH2:1][C:2](=[N:27][N+:28]([O-:30])=[O:29])[NH:3][CH2:4][CH2:5][CH2:6][C@H:7]([C:16]([NH:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([OH:26])=[CH:24][CH:25]=1)=[O:17])[NH2:8].[F:31][C:32]([F:37])([F:36])[C:33]([O-:35])=[O:34]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 136381091HCID 136381091, compound

Product 1

HCID 136381089HCID 136381089, compoundYield 70%

Procedure

Prepared analogously to Example 5e) from (R)-N5 -[amino(nitroimino)methyl]-N2 -(tert.-butoxycarbonyl)-N-[(4-hydroxyphenyl)methyl]-ornithinamide and trifluoroacetic acid in a yield of 70% of theory. Colourless amorphous substance Rf 0.3 (test conditions as in Example 9a).

Sources & evidence

ORD record: ord-fc0f60e33ba24573908c6b12e635c8e4
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05807875

Reaction notes

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