HRID2393651

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1ccc(CNC(=O)[C@H](CCCNC(N)=N[N+](=O)[O-])NC(=O)C(c2ccccc2)c2ccccc2)cc1OC

HCID136381101

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(CNC(=O)[C@H](CCCNC(=N)N)NC(=O)C(c2ccccc2)c2ccccc2)cc1OC

HCID178491207

未命名化合物

收率 58%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID176

Acetic Acid

C2H4O2

PROCEDURE

实验过程

Prepared analogously to Example 1c) from N5 -[amino(nitroimino)methyl)-N-[(3,4-dimethoxyphenyl)-methyl]-N2 -(diphenylacetyl)-ornithinamide by catalytic hydrogenation in the presence of palladium black and 80% aqueous acetic acid in a yield of 58% of theory. Colourless amorphous substance Rf 0.62.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2166054e1f694e678dbe7e28f700f544
来源数据集: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05807875
来源说明: uspto-grants-1998_09

反应 SMILES

[NH2:1][C:2](=[N:38][N+]([O-])=O)[NH:3][CH2:4][CH2:5][CH2:6][C@@H:7]([C:24]([NH:26][CH2:27][C:28]1[CH:33]=[CH:32][C:31]([O:34][CH3:35])=[C:30]([O:36][CH3:37])[CH:29]=1)=[O:25])[NH:8][C:9](=[O:23])[CH:10]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>[Pd].C(O)(=O)C>[CH3:37][O:36][C:30]1[CH:29]=[C:28]([CH2:27][NH:26][C:24](=[O:25])[C@H:7]([CH2:6][CH2:5][CH2:4][NH:3][C:2](=[NH:1])[NH2:38])[NH:8][C:9](=[O:23])[CH:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH:33]=[CH:32][C:31]=1[O:34][CH3:35]