Hydrazine hydrate (1:1) → HCID 18977136, compound

HRID 2393735Notes

Reaction equation

HRID 2393735 reaction equation
O.[NH2:2][NH2:3].[CH3:4][CH:5]([CH2:20][CH2:21][N:22]1C(=O)C2=CC=CC=C2C1=O)[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13](=O)[CH2:14][CH2:15][C:16](O)=[O:17])=[CH:9][CH:8]=1>C(O)C>[NH2:22][CH2:21][CH2:20][CH:5]([CH3:4])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH2:14][CH2:15][C:16](=[O:17])[NH:2][N:3]=2)=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 18977141HCID 18977141, compound

Product 1

HCID 18977136HCID 18977136, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

9.61 g of hydrazine monohydrate was added to an ethanol solution (500 ml) containing 15.06 g of 4-(2-methyl-4-phthalimidobutyl)-1-(3-hydroxycarbonylpropionyl)benzene, and the mixture was refluxed under heating for 2.5 hours. After cooling, precipitated crystal was collected by filtration and recrystallized from ethyl acetate to obtain 8.14 g of 6-[4-(4-amino-2-methylbutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one.

Workup

  1. temperaturethe mixture was refluxed
  2. temperatureunder heating for 2.5 hours
  3. temperatureAfter cooling
  4. customprecipitated crystal
  5. filtrationwas collected by filtration
  6. customrecrystallized from ethyl acetate

Sources & evidence

ORD record
ord-f8b99e4394ac4671848fb241e21785ef
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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