Dimethyl Sulfoxide → HCID 18977180, compound

HRID 2393736Notes

Reaction equation

HRID 2393736 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH2:13][CH2:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:8][CH:7]=1.[BrH:19].C(O)(=O)C.CS(C)=O.C(OC(C)C)(C)C>C(O)(=O)C>[BrH:19].[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]2[CH:13]=[CH:14][C:15](=[O:18])[NH:16][N:17]=2)=[CH:10][CH:11]=1

Participants

6

Reactant 4

HCID 679Dimethyl SulfoxideHCID 7914Diisopropyl EtherHCID 18977184HCID 18977184, compoundHCID 21893785Acetic Acid Mixture with Hydrobromic Acid

Product 1

HCID 18977180HCID 18977180, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In 200 ml of acetic acid was suspended 15.00 g of 6-[4-(4-aminobutyl)phenyl]-4,5-dihydropyridazin-3(2H)-one. To the suspension were added 100 ml of a 25% hydrogen bromide-acetic acid solution and then 5.35 g of dimethylsulfoxide, and the mixture was stirred at room temperature for 4.5 hours. 400 ml of isopropyl ether was added to the reaction mixture, and precipitated crystal was collected by filtration and recrystallized from methanol to obtain 18.94 g of 6-[4-(4-aminobutyl)phenyl]pyridazin-3(2H)-one hydrobromide.

Workup

  1. customprecipitated crystal
  2. filtrationwas collected by filtration
  3. customrecrystallized from methanol

Sources & evidence

ORD record
ord-2261f0e9b39b48fbb6b01f54c9e9a307
Source dataset
uspto-grants-1998_09
Patent number
US05808065

Reaction notes

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