Triethylamine → HCID 86753120, compound

HRID 2394043Notes

Reaction equation

HRID 2394043 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=1)[O:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])(=[O:3])[CH3:2].C(N(CC)CC)C.[C:24]1([CH2:30][CH2:31][S:32][CH:33]([C:37](O)=[O:38])[C:34](O)=[O:35])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>C(Cl)Cl>[OH:38][C:37]1[CH:2]=[C:1]([C:4]2[CH:5]=[C:6]([CH:14]=[CH:15][CH:16]=2)[O:7][CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[O:3][C:34](=[O:35])[C:33]=1[S:32][CH2:31][CH2:30][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2727490HCID 2727490, compoundHCID 19596072[(Phenylethyl)thio]propanedioic acid

Product 1

HCID 86753120HCID 86753120, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared by Method A using ethyl (3-acetylphenoxy)acetate (2.00 g, 9.00 mmol), trimethyl silyltriflate (4.18 mL, 21.62 mmol), triethylamine (5.01 mL, 36.00 mmol), methylene chloride (23 mL), and diethyl ester of [(2-phenylethyl)thio]propanedioic acid (1.00 g, 3.37 mmol). m.p. 116°-119° C.; 1H NMR (400 MHz, DMSO-d6) δ 1.22 (t, 3H), 2.77 (t, 2H), 3.05 (t, 2H), 4.89 (d, 2H), 6.80 (s, 1H), 7.20 (m, 7H), 7.44 (m, 2H).

Sources & evidence

ORD record
ord-d7fada41b3b14216ad83fd934700cb81
Source dataset
uspto-grants-1998_09
Patent number
US05808062

Reaction notes

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