Trifluoroacetic acid → 2H-(1)Benzothiopyrano(4,3,2-cd)indazole, 2-(2-(diethylamino)ethyl)-5-methyl-

HRID 2394079Notes

Reaction equation

HRID 2394079 reaction equation
[CH3:1][CH2:2][NH+:3]([CH2:6][CH2:7][N:8]1[N:20]=[C:19]2[C:10]3[C:11]([S:16][C:17]4[CH:24]=[C:23](Cl)[CH:22]=[CH:21][C:18]=42)=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]1=3)[CH2:4][CH3:5].CS([O-])(=O)=O.CCN(CCN1N=C2C3C(SC4C=C(Cl)C=CC=42)=C(CO)C=CC1=3)CC.FC(F)(F)C(O)=O>O>[CH3:5][CH2:4][N:3]([CH2:6][CH2:7][N:8]1[N:20]=[C:19]2[C:10]3[C:11]([S:16][C:17]4[C:18]2=[CH:21][CH:22]=[CH:23][CH:24]=4)=[C:12]([CH3:15])[CH:13]=[CH:14][C:9]1=3)[CH2:2][CH3:1]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 322498-Chloro-2-(2-(diethylamino)ethyl)-2H-(1)benzothiopyrano(4,3,2-cd)indazole-5-methanolHCID 39422IA 3 methanesulfonate

Product 1

HCID 322472H-(1)Benzothiopyrano(4,3,2-cd)indazole, 2-(2-(diethylamino)ethyl)-5-methyl-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the compounds according to Example Ia-3 and Ia-4 (cis-trans mixture) (300 mg), trifluoroacetic acid (10 ml) and water (10 ml) is stirred at room temperature for 24 hours and concentrated. The solid residue is washed with hot cyclohexane.

Workup

  1. additionA mixture of the compounds
  2. concentrationconcentrated
  3. washThe solid residue is washed with hot cyclohexane

Sources & evidence

ORD record
ord-ecf3a398c8b242da930ecd4af6e70431
Source dataset
uspto-grants-1998_09
Patent number
US05808135

Reaction notes

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