Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-(4-Bromobenzyl)-5-methoxy-2-methylindole-3-acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | HCID 54300597 | HCID 54300597 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1-(4-Bromobenzyl)-5-methoxy-2-methylindole-3-acetic acid | HCID 10810285 | 98.3% |
반응 단계
A solution of methyl 1-(4-bromobenzyl)-5-methoxy-2-methylindole-3-acetate (10 g, 24.9 mmol) and KOH (1.7 g, 30 mmol) in 45 mL of THF, 5 mL of H2O, and 2 mL of methanol was heated at reflux for 1 h. The reaction mixture was cooled to 0° C. and neutralized with concentrated HCl. The solvent volume was reduced by rotary evaporation. The precipitate was collected and washed with H2O. The white solid was dried in a vacuum oven to give 9.5 g (98%) of the carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05811425 |
| 출처 데이터셋 | uspto-grants-1998_09 |
| ORD ID | ord-8d56a8b8602a4aa1b2296da60f790b91 |
| 출처 메모 | uspto-grants-1998_09 |