Water → 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic Acid

HRID 2394273Notes

Reaction equation

HRID 2394273 reaction equation
[Cl:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12](Cl)=[O:13])=[CH:4][N:3]=1.[OH2:15]>>[Cl:1][C:2]1[N:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[C:5]([C:12]([OH:13])=[O:15])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 962WaterHCID 27367082-Chloro-4-(trifluoromethyl)pyrimidine-5-carbonyl chloride

Product 1

HCID 108231502-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylic AcidYield 98%

Procedure

A solution of 2-chloro-4-trifluoromethylpyrimidine-5-carbonyl chloride (2.1 g, 8.6 mmol) in H2O (10 mL) was stirred at 0° C. under N2 for 0.5 h. The resulting solid was filtered and dried to give the title compound (1.91 g, 98% yield); m.p. 232°-234° C. (dec.).

Workup

  1. filtrationThe resulting solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-2925b45915284bee82450be7a2476a3e
Source dataset
uspto-grants-1998_09
Patent number
US05811428

Reaction notes

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