Methane → HCID 178524757, compound

HRID 2394285Notes

Reaction equation

HRID 2394285 reaction equation
[Cl:1][C:2]1[C:3]([Cl:14])=[N:4][CH:5]=[C:6]([C:12]=1[OH:13])[C:7]([O:9]CC)=[O:8].[OH-].[K+].C>O>[Cl:1][C:2]1[C:3]([Cl:14])=[N:4][CH:5]=[C:6]([C:12]=1[OH:13])[C:7]([OH:9])=[O:8]

Participants

5

Reactant 3

HCID 297MethaneHCID 14797Potassium HydroxideHCID 178469782HCID 178469782, compound

Product 1

HCID 178524757HCID 178524757, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

114 g (0.483 mol) of ethyl 5,6-dichloro-4-hydroxy-nicotinate are boiled under reflux in 1200 ml of water with 58 g (1.03 mol) of potassium hydroxide for two hours. The cooled mixture is stirred with activated charcoal and filtered, and the filtrate is brought to a pH of 1 with half-concentrated hydrochloric acid, while cooling with ice. The product which precipitates is isolated, washed with water and dried.

Workup

  1. filtrationfiltered
  2. temperaturewhile cooling with ice
  3. customThe product which precipitates
  4. customis isolated
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-47537fb97ae54bbc8109503c94fd9ade
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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