Water → HCID 18973168, compound

HRID 2394292Notes

Reaction equation

HRID 2394292 reaction equation
[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([O:18]CC)=[O:17])=[CH:8][N:9]2[CH2:13][CH2:14][F:15])=[CH:4][N:3]=1.O.S(=O)(=O)(O)O>C(O)(=O)C>[Cl:1][C:2]1[C:11]([Cl:12])=[C:10]2[C:5]([C:6](=[O:21])[C:7]([C:16]([OH:18])=[O:17])=[CH:8][N:9]2[CH2:13][CH2:14][F:15])=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 1118Sulfuric AcidHCID 18973167HCID 18973167, compound

Product 1

HCID 18973168HCID 18973168, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.33 g (0.01 mol) of ethyl 7,8-dichloro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate are heated at reflux in a mixture of 13 ml of acetic acid, 13 ml of water and 1.3 ml of concentrated sulphuric acid for two hours. The cooled mixture is put into ice-water, and the product is isolated and washed with water.

Workup

  1. customthe product is isolated
  2. washwashed with water

Sources & evidence

ORD record
ord-21122f44744c4f7ab6fd5dca64010ea3
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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