Water → HCID 18973168, compound

Participants

Reaction Steps

3.33 g (0.01 mol) of ethyl 7,8-dichloro-1-(2-fluoroethyl)-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylate are heated at reflux in a mixture of 13 ml of acetic acid, 13 ml of water and 1.3 ml of concentrated sulphuric acid for two hours. The cooled mixture is put into ice-water, and the product is isolated and washed with water.

Provenance & Evidence