反应详情

A solution of ˜16% HCl in methanol (25 ml) was added to a solution of compound 23 (300 ng, 1.23 mmol) in absolute methanol (5 ml). (Upon addition of the acid, all insoluble material was dissolved). The reaction mixture was stirred at room temperature. After 10 min, a yellow powder was precipitated; the mixture was stirred overnight. The product was then filtered and washed with absolute methanol (5 ml×2). The product was obtained as a yellow powder in quantitative yield. TLC and the m.p. showed the product to be identical to that obtained previously.

1. addition(Upon addition of the acid
2. dissolutionall insoluble material was dissolved)
3. customa yellow powder was precipitated
4. stirringthe mixture was stirred overnight
5. filtrationThe product was then filtered
6. washwashed with absolute methanol (5 ml×2)
7. customThe product was obtained as a yellow powder in quantitative yield
8. customthat obtained previously