Hydrochloric Acid → HCID 178432864, compound

HRID 2394300Notes

Reaction equation

HRID 2394300 reaction equation
[Cl:1][C:2]1[C:3]([Cl:15])=[N:4][C:5]([CH3:14])=[C:6]([C:12]=1[OH:13])[C:7]([O:9]CC)=[O:8].O.[OH-].[K+].Cl>C(O)C>[Cl:1][C:2]1[C:3]([Cl:15])=[N:4][C:5]([CH3:14])=[C:6]([C:12]=1[OH:13])[C:7]([OH:9])=[O:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14797Potassium HydroxideHCID 178469225HCID 178469225, compound

Product 1

HCID 178432864HCID 178432864, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

36 g (0.14 mol) of ethyl 5,6-dichloro-4-hydroxy-2-methyl-nicotinate are boiled under reflux in 88 ml of ethanol and 175 ml of water with 24.2 g (0.43 mol) of potassium hydroxide for thirty minutes. The cooled mixture is brought to a pH of 1 with half-concentrated hydrochloric acid, while cooling with ice. The product which precipitates is isolated, washed with water and dried.

Workup

  1. temperaturewhile cooling with ice
  2. customThe product which precipitates
  3. customis isolated
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-b3add6662e7f40dfa31adfb24b620909
Source dataset
uspto-grants-1998_09
Patent number
US05811433

Reaction notes

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