Indole-4-carboxaldehyde → HCID 18973527, compound

HRID 2394405Notes

Reaction equation

HRID 2394405 reaction equation
[NH:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1.[F:12][C:13]1[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br>>[F:12][C:13]1[C:20]([F:21])=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][N:1]1[C:9]2[CH:8]=[CH:7][CH:6]=[C:5]([CH:10]=[O:11])[C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 333703Indole-4-carboxaldehydeHCID 5179841-(Bromomethyl)-2,3-difluoro-benzene

Product 1

HCID 18973527HCID 18973527, compoundYield 77.6%

Procedure

The same procedures used in Example 1 were repeated except for using 580 mg of indole-4-carbaldehyde and 911 mg of 2,3-difluorobenzyl bromide in place of the benzyl bromide used in Example 1 to give 841 mg of 1-(2,3-difluorobenzyl)indole-4-carbaldehyde as pale brown crystals. The yield thereof was found to be 76%.

Sources & evidence

ORD record
ord-69f02546f12a4982a8910be803175d1d
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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