Phenacyl bromide → HCID 18973554, compound

HRID 2394424Notes

Reaction equation

Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[NH:11]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:20]=[O:21])[C:14]=2[CH:13]=[CH:12]1>>[CH2:2]([N:11]1[C:19]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:20]=[O:21])[C:14]=2[CH:13]=[CH:12]1)[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4]

Participants

Reactant 2

HCID 6259Phenacyl bromide

HCID 333703Indole-4-carboxaldehyde

Product 1

HCID 18973554HCID 18973554, compoundYield 13.6%

Procedure

The same procedures used in Example 7 were repeated except for using 5.49 g of bromoacetophenone and 2.00 g of indole-4-carbaldehyde as a starting material to give 494 mg of 1-phenacylindole-4-carbaldehyde as yellow crystals. The yield thereof was found to be 14%.

Sources & evidence

ORD record: ord-81adb96d980d47c9aef4511dfc2aedc0
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811439

Reaction notes

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