Indole-3-Carboxaldehyde → HCID 18973548, compound

HRID 2394439Notes

Reaction equation

HRID 2394439 reaction equation
[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH2:4]Br.[NH:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=[O:21])=[CH:12]1>>[F:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[CH2:4][N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH:20]=[O:21])=[CH:12]1

Participants

3

Reactant 2

HCID 10256Indole-3-CarboxaldehydeHCID 5228302-(Bromomethyl)-1,4-difluorobenzene

Product 1

HCID 18973548HCID 18973548, compoundYield 92.6%

Procedure

The same procedures used in Example 1 were repeated except for using 3.06 g of 2,5-difluorobenzyl bromide and 2.00 g of indole-3-carbaldehyde as a starting material to give 3.46 g of 1-(2,5-difluorobenzyl)indole-3-carbaldehyde as pale yellow crystals. The yield thereof was found to be 93%.

Sources & evidence

ORD record
ord-c5629619d27e414a94325fd572aafb16
Source dataset
uspto-grants-1998_09
Patent number
US05811439

Reaction notes

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