2,2,2-trichloro-N-ethylacetamide → 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminocarbonyl-aminosulfonyl)-7-methoxychroman

HRID 2394458Notes

Reaction equation

HRID 2394458 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8].[CH2:30]([NH:32][C:33](=[O:38])C(Cl)(Cl)Cl)[CH3:31]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21]([NH:22][C:33]([NH:32][CH2:30][CH3:31])=[O:38])(=[O:23])=[O:24])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8]

Participants

3

Reactant 2

HCID 41086712,2,2-trichloro-N-ethylacetamideHCID 110484644-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman

Product 1

HCID 189736154-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminocarbonyl-aminosulfonyl)-7-methoxychroman

Procedure

4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminocarbonyl-aminosulfonyl)-7-methoxychroman ##STR32## 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(ethylaminocarbonyl-aminosulfonyl)-7-methoxychroman is synthesized analogously to Example 1 from 4-(5-chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman and N-ethyltrichloroacetamide. Melting point: 211°-213° C.

Sources & evidence

ORD record
ord-3add8c00ce544a3386bfb153a05178fd
Source dataset
uspto-grants-1998_09
Patent number
US05811448

Reaction notes

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