Butyl Isothiocyanate → 4-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-butylaminothiocarbonylaminosulfonyl)-7-methoxychroman

HRID 2394462Notes

Reaction equation

HRID 2394462 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21](=[O:24])(=[O:23])[NH2:22])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8].[CH2:30]([N:34]=[C:35]=[S:36])[CH2:31][CH2:32][CH3:33]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:28][CH3:29])=[C:6]([CH:27]=1)[C:7]([NH:9][CH2:10][CH:11]1[C:20]2[C:15](=[CH:16][C:17]([O:25][CH3:26])=[C:18]([S:21]([NH:22][C:35]([NH:34][CH2:30][CH2:31][CH2:32][CH3:33])=[S:36])(=[O:23])=[O:24])[CH:19]=2)[O:14][CH2:13][CH2:12]1)=[O:8]

Participants

3

Reactant 2

HCID 11613Butyl IsothiocyanateHCID 110484644-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman

Product 1

HCID 539103374-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-butylaminothiocarbonylaminosulfonyl)-7-methoxychroman

Procedure

4-(5-Chloro-2-methoxybenzamidomethyl)-6-(n-butylaminothiocarbonylaminosulfonyl)-7-methoxychroman is prepared analogously to Example 4 from 4-(5-chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman and n-butyl isothiocyanate. Melting point: 167° C.

Sources & evidence

ORD record
ord-dc77a97af1cc434b865a29bfe2974cd6
Source dataset
uspto-grants-1998_09
Patent number
US05811448

Reaction notes

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