Hydrogen Peroxide → HCID 18973649, compound

HRID 2394473Notes

Reaction equation

[CH2:1]([C:3]1[C:4](=[O:34])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:31][CH2:32][CH3:33])=[C:20]([S:23]([NH:26][C:27]([NH:29][CH3:30])=S)(=[O:25])=[O:24])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2].[OH:35]O>>[CH2:1]([C:3]1[C:4](=[O:34])[N:5]([C:9]([NH:11][CH2:12][CH:13]2[C:22]3[C:17](=[CH:18][C:19]([O:31][CH2:32][CH3:33])=[C:20]([S:23]([NH:26][C:27]([NH:29][CH3:30])=[O:35])(=[O:25])=[O:24])[CH:21]=3)[O:16][CH2:15][CH2:14]2)=[O:10])[CH2:6][C:7]=1[CH3:8])[CH3:2]

Participants

Reactant 2

HCID 784Hydrogen Peroxide

HCID 57283766HCID 57283766, compound

Product 1

HCID 18973649HCID 18973649, compound

Procedure

4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(methylaminocarbonylaminosulfonyl)-7-ethoxychroman ##STR56## 4-((3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(methylaminocarbonylaminosulfonyl)-7-ethoxychroman is prepared analogously to Example 18 by oxidation of 4-((3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) methyl)-6-(methylaminothiocarbonylaminosulfonyl)-7-ethoxychroman using hydrogen peroxide solution. Melting point: 187°-188° C.

Sources & evidence

ORD record: ord-25669c12f68a4cbcb54767e920558c52
Source dataset: uspto-grants-1998_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05811448

Reaction notes

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