HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trichloro-n-methylacetamide → (+)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trichloro-n-methylacetamide | HCID 248652 | — |
| Reactant | 4-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman | HCID 11048464 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (+)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman | HCID 11755624 | — |
Reaction Steps
(-)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman ##STR60## (-)-4-(5-Chloro-2-methoxy-benzamidomethyl)-6-(methylaminocarbonyl-aminosulfonyl)-7-methoxychroman is prepared analogously to Example 1 from optically active 4-(5-chloro-2-methoxybenzamido methyl)-6-sulfamoyl-7-methoxychroman and N-methyltrichloroacetamide. Melting point: 239° C.; [α]D20 : -59.8° (c=1, DMF); HPLC: ee 98.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811448 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-a0866739151544709e86a8258e55171e |
| Source note | uspto-grants-1998_09 |