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HRID2394476

反应详情

EQUATION

反应方程式

HRID 2394476 的结构方程式

REACTANTS

反应物

2
结构：CNC(=O)C(Cl)(Cl)Cl
HCID248652

2,2,2-trichloro-n-methylacetamide

C3H4Cl3NO

结构：COc1ccc(Cl)cc1C(=O)NCC1CCOc2cc(OC)c(S(N)(=O)=O)cc21
HCID11048464

未命名化合物

PRODUCTS

生成物

1
结构：CNC(=O)NS(=O)(=O)c1cc2c(cc1OC)OCCC2CNC(=O)c1cc(Cl)ccc1OC
HCID11755624

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

(-)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminocarbonylaminosulfonyl)-7-methoxychroman ##STR60## (-)-4-(5-Chloro-2-methoxy-benzamidomethyl)-6-(methylaminocarbonyl-aminosulfonyl)-7-methoxychroman is prepared analogously to Example 1 from optically active 4-(5-chloro-2-methoxybenzamido methyl)-6-sulfamoyl-7-methoxychroman and N-methyltrichloroacetamide. Melting point: 239° C.; [α]D20 : -59.8° (c=1, DMF); HPLC: ee 98.5%.