HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl isothiocyanate → HCID 9871110, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl isothiocyanate | HCID 11167 | — |
| Reactant | 4-(5-Chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman | HCID 11048464 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 9871110 | HCID 9871110 | — |
Reaction Steps
(-)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminothiocarbonylaminosulfonyl)-7-methoxychroman ##STR61## (-)-4-(5-Chloro-2-methoxybenzamidomethyl)-6-(methylaminothiocarbonyl-aminosulfonyl)-7-methoxychroman is prepared as described in Example 4 from optically active 4-(5-chloro-2-methoxybenzamidomethyl)-6-sulfamoyl-7-methoxychroman and methyl isothiocyanate. Melting point: 202° C., [α]D20 : -64.5° (c=1, DMF); HPLC: ee 97.9%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05811448 |
| Source dataset | uspto-grants-1998_09 |
| ORD ID | ord-c003cebd903a4d60a4d1b15341e43e29 |
| Source note | uspto-grants-1998_09 |