反应详情

Methyl 1-acetyl-2,3-dihydroindol-3-one-6-carboxylate (233 mg, 1 mmol), trimethyl orthoformate (10 ml) and p-toluene sulphonic acid (20 mg) were heated under reflux for 3 h. in methanol (10 ml). The reaction mixture was concentrated under reduced pressure, poured into water and extracted with chloroform. After drying and evaporation, the product was purified by prep hplc;

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. additionpoured into water
3. extractionextracted with chloroform
4. customAfter drying
5. customevaporation
6. customthe product was purified by prep hplc