反应详情

15 b. 4-(3-Cyclopentyloxy-4-methoxyphenyl)-4-(hydroxymethyl)cyclohexan-1-one 4-(3-Cyclopentyloxy-4-methoxyphenyl)-4 (hydroxymethyl)cyclohexan-1-one dimethyl ketal (0.15 g, 0.41 mmol) in ether (2 mL) was treated with 1N hydrochloric acid (2 mL) and the mixture was snared vigorously and gently heated for 10 min. The mixture was extracted with ether, the combined organic extracts were washed with 5% aqueous sodium carbonate, dried (potassium carbonate) and the solvent was removed in vacuo. Purification by flash chromatography, eluting with 25% ethyl acetate/chloroform, provided a wax (0.06 g, 56%).

1. temperaturegently heated for 10 min
2. extractionThe mixture was extracted with ether
3. washthe combined organic extracts were washed with 5% aqueous sodium carbonate
4. dry with materialdried (potassium carbonate)
5. customthe solvent was removed in vacuo
6. customPurification by flash chromatography
7. washeluting with 25% ethyl acetate/chloroform
8. customprovided a wax (0.06 g, 56%)