Thionyl Chloride → 2-Methyl-3,4,6-trifluorobenzoyl chloride

HRID 2394938Notes

Reaction equation

HRID 2394938 reaction equation
[CH3:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:16])=O>>[CH3:1][C:2]1[C:10]([F:11])=[C:9]([F:12])[CH:8]=[C:7]([F:13])[C:3]=1[C:4]([Cl:16])=[O:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 101303052-Methyl-3,4,6-trifluorobenzoic acid

Product 1

HCID 150076072-Methyl-3,4,6-trifluorobenzoyl chloride

Procedure

To 2-methyl-3,4,6-trifluorobenzoic acid (3.2 g) is added thionyl chloride (7 ml) and the mixture is refluxed for 1 hour. After concentrating, 2-methyl-3,4,6-trifluorobenzoyl chloride (3.3 g) is obtained.

Workup

  1. temperaturethe mixture is refluxed for 1 hour
  2. concentrationAfter concentrating

Sources & evidence

ORD record
ord-4c1ec2bcaa5b475f9759e36bc5507d2d
Source dataset
uspto-grants-1998_09
Patent number
US05811576

Reaction notes

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