Hydrochloric Acid → HCID 14651266, compound

HRID 2394948Notes

Reaction equation

HRID 2394948 reaction equation
[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:15])[C:9]([F:14])=[C:10]([F:13])[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([O:19]CC)=[O:18])=[CH:4]1)[CH3:2].Cl>C(O)(=O)C>[CH2:1]([N:3]1[C:12]2[C:7](=[C:8]([CH3:15])[C:9]([F:14])=[C:10]([F:13])[CH:11]=2)[C:6](=[O:16])[C:5]([C:17]([OH:19])=[O:18])=[CH:4]1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14651267Ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate

Product 1

HCID 14651266HCID 14651266, compoundYield 80.4%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Employing ethyl 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate (0.55 g), conc. hydrochloric acid (1.5 ml) and 90% acetic acid (6 ml), the procedure of Reference Example 10 is repeated to give 1-ethyl-5-methyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (0.40 g), as white crystals, m.p.>300° C.

Sources & evidence

ORD record
ord-76c1b9ffbe044c309642053ab25499ce
Source dataset
uspto-grants-1998_09
Patent number
US05811576

Reaction notes

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