Hydrochloric Acid → HCID 10493689, compound

Participants

Reaction Steps

N-(2,2-Diethoxyethyl)-N'-[4-(2,2,3,3-tetrafluoropropoxy)phenyl] urea (37.5 g) was dissolved in a mixture of 560 ml of methanol and 280 ml of water. To the solution was added 300 ml of an aqueous solution containing 0.48M of hydrochloric acid and the mixture was stirred at room temperature for 3 days. The reaction mixture was concentrated under reduced pressure and the precipitated crystals were washed with a mixture of water-methanol (5:1) to give 22.8 g of 1-[4-(2,2,3,3-tetrafluoropropoxy)phenyl]-2-(1H,3H)-imidazolone as colorless powder.

Provenance & Evidence